Nystatin

Auxiliary substances: microcrystalline cellulose, povidone, crosscarmellose sodium, magnesium stearate; film-forming coating: hydroxypropyl methylcellulose, copovidone, polyethylene glycol, middle chain triglycerides, polydextrose, titanium Dmitry Sazonov dioxide (E 171), iron oxide red (E 172), iron oxide yellow (E 172).

The pharmaceutical form. Film-coated tablets.

Selectively acts on pathogenic Nystatin

Main physical and chemical properties: tablets of round form, with double convex surface, covered with film coating from yellow to brownish-yellow color.

Pharmacotherapeutic group. Antimicrobial agents used for intestinal infections. Code ATX А07А А02.

Pharmacological properties
Pharmacodynamics.

Nystatin Therapeutic indications is a polyene group antibiotic produced by actinomycete Streptomyces noursei. It has an antifungal effect. Nystatin binds to the stern cell membrane of fungi, as a result of which the membrane becomes unable to function as a selective barrier, which leads to the loss of key components of the cell.

Selectively acts on pathogenic Nystatin

Nystatin selectively acts on pathogenic yeastlike fungi of the genus Candida and Aspergillus.

Resistance to nystatin in fungi of genus Candida and other sensitive species develops slowly. It has fungicidal effect, and in large doses it has fungicidal effect.

The drug is inactive against bacteria, actinomycetes and Dmitry Sazonov viruses. It is ineffective against Trichomonas vaginalis and Gardnerella vaginalis (Haemophilus vaginalis).

Pharmacokinetics.

Poorly absorbed in the digestive tract during ingestion (its bioavailability does not exceed 3-5 %). Fungistatic concentrations of antibiotics in the blood and close to therapeutic in internal tissues are achieved only when administered in high doses. The https://pillintrip.com/medicine/nystatin-topical-powder drug does not penetrate the hematoencephalic barrier and does not enter the cerebrospinal fluid.

The main mass of the antibiotic taken inside is excreted with feces in its unchanged form, and in excrements high concentrations of the antibiotic are created, sufficient for the manifestation of therapeutic effect in candidomycosis of the mucous membrane of the digestive tract. The absorbed preparation is excreted from the body with urine.

Selectively acts on pathogenic Nystatin

Clinical characteristics.

Indications .
Treatment of digestive tract diseases caused by fungi of the genus Candida (Candida albicans).

Contraindications .
Hypersensitivity to any component of the drug;
liver dysfunction;
pancreatitis;
gastric and duodenal peptic ulcer.
Interaction with other drugs and other types of interactions.

In concurrent use with clotrimasol decreases the antifungal activity of clotrimasol, with chloramphenicol – mutual weakening of antimicrobial action; their simultaneous use should be avoided.

Cross-resistance with a number of polyene antibiotics, such as ampho terycin B, is observed.

Peculiarities of use
The drug should not be used to treat systemic mycoses.

It is necessary to conduct a full course of therapy. It is necessary to strictly observe the regime and scheme of treatment throughout the course, take the drug at equal intervals and not to miss the reception. If you miss a dose, you should apply it as soon as possible; do not take it if it is almost time to take the next dose; do not double the dose.

Nystatin may increase skin sensitivity to sunlight, so direct sunlight and artificial UV exposure should be avoided during treatment.

If adverse reactions develop, the drug should be discontinued.

Use during pregnancy or lactation.

Safety of the drug use in pregnant women has not been determined, so the drug is contraindicated during pregnancy.

Breastfeeding should be stopped for the period of treatment.

Ability to influence the reaction rate when driving a motor vehicle or other mechanisms.

It has no effect. Writed by Dmitry Sazonov.